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Il participe activement la dtoxification des substances nocives et aide protger les cellules hpatiques contre les toxines environnementales, les mdicaments et l'alcool

Since ROS-dependent DNA damage is markedly increased in myeloid cells after Bcr-Abl transformation 18 , we hypothesize that blocking dTTP and dCTP supply might exacerbate replication stress and DNA damage in Bcr-Abl-transformed cells, thereby jeopardizing cell survival

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So far, the documented primary early PD metabolic pathway alterations include oxidative stress (significantly lower levels of dehydroascorbic acid than controls), carbohydrate metabolism (significantly higher levels of fructose, mannose, and threonine), lipid metabolism (e.g., sphingolipids or phospholipids), amino acid metabolism (lower levels of 3-hydroxyisovaleric acid and tryptophan and higher levels of leucine, isoleucine, and ketoleucine than controls), and fatty acid oxidation (lower levels of creatinine) (Wang J